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Human T(H)17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation
T(H)17 lymphocytes appear to be essential in the pathogenesis of numerous inflammatory diseases. We demonstrate here the expression of IL-17 and IL-22 receptors on blood-brain barrier endothelial cells (BBB-ECs) in multiple sclerosis lesions, and show that IL-17 and IL-22 disrupt BBB tight junctions...
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| Publicat a: | Nat Med |
|---|---|
| Autors principals: | , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5114125/ https://ncbi.nlm.nih.gov/pubmed/17828272 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm1651 |
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