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Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms

PURPOSE: Netarsudil is a Rho kinase/norepinephrine transporter inhibitor currently in phase 3 clinical development for glaucoma treatment. We investigated the effects of its active metabolite, netarsudil-M1, on outflow facility (C), outflow hydrodynamics, and morphology of the conventional outflow p...

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Опубликовано в: :Invest Ophthalmol Vis Sci
Главные авторы: Ren, Ruiyi, Li, Guorong, Le, Thuy Duong, Kopczynski, Casey, Stamer, W. Daniel, Gong, Haiyan
Формат: Artigo
Язык:Inglês
Опубликовано: The Association for Research in Vision and Ophthalmology 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114035/
https://ncbi.nlm.nih.gov/pubmed/27842161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.16-20189
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