Expression of heavy chain‐only antibodies can support B‐cell development in light chain knockout chickens

Since the discovery of antibody‐producing B cells in chickens six decades ago, chickens have been a model for B‐cell development in gut‐associated lymphoid tissue species. Here we describe targeting of the immunoglobulin light chain locus by homologous recombination in chicken primordial germ cells...

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Detalhes bibliográficos
Publicado no:Eur J Immunol
Main Authors: Schusser, Benjamin, Collarini, Ellen J., Pedersen, Darlene, Yi, Henry, Ching, Kathryn, Izquierdo, Shelley, Thoma, Theresa, Lettmann, Sarah, Kaspers, Bernd, Etches, Robert J., van de Lavoir, Marie‐Cecile, Harriman, William, Leighton, Philip A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Adaptive immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5113765/
https://ncbi.nlm.nih.gov/pubmed/27392810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201546171
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