Glutathione deficiency leads to mitochondrial damage in brain.

Glutathione deficiency induced in newborn rats by giving buthionine sulfoximine, a selective inhibitor of gamma-glutamylcysteine synthetase, led to markedly decreased cerebral cortex glutathione levels and striking enlargement and degeneration of the mitochondria. These effects were prevented by giv...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Jain, A, Mårtensson, J, Stole, E, Auld, P A, Meister, A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1991
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51136/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2000395/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.5.1913
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