Controlled Mycobacterium tuberculosis infection in mice under treatment with anti-IL-17A or IL-17F antibodies, in contrast to TNFα neutralization

Antibodies targeting IL-17A or its receptor IL-17RA show unprecedented efficacy in the treatment of autoimmune diseases such as psoriasis. These therapies, by neutralizing critical mediators of immunity, may increase susceptibility to infections. Here, we compared the effect of antibodies neutralizi...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Segueni, Noria, Tritto, Elaine, Bourigault, Marie-Laure, Rose, Stéphanie, Erard, François, Le Bert, Marc, Jacobs, Muazzam, Di Padova, Franco, Stiehl, Daniel P., Moulin, Pierre, Brees, Dominique, Chibout, Salah-Dine, Ryffel, Bernhard, Kammüller, Michael, Quesniaux, Valerie F.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5113257/
https://ncbi.nlm.nih.gov/pubmed/27853279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36923
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