Controlled Mycobacterium tuberculosis infection in mice under treatment with anti-IL-17A or IL-17F antibodies, in contrast to TNFα neutralization

Antibodies targeting IL-17A or its receptor IL-17RA show unprecedented efficacy in the treatment of autoimmune diseases such as psoriasis. These therapies, by neutralizing critical mediators of immunity, may increase susceptibility to infections. Here, we compared the effect of antibodies neutralizi...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Segueni, Noria, Tritto, Elaine, Bourigault, Marie-Laure, Rose, Stéphanie, Erard, François, Le Bert, Marc, Jacobs, Muazzam, Di Padova, Franco, Stiehl, Daniel P., Moulin, Pierre, Brees, Dominique, Chibout, Salah-Dine, Ryffel, Bernhard, Kammüller, Michael, Quesniaux, Valerie F.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5113257/
https://ncbi.nlm.nih.gov/pubmed/27853279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36923
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