Feasibility and Safety of RNA-transfected CD20-specific Chimeric Antigen Receptor T Cells in Dogs with Spontaneous B Cell Lymphoma

Preclinical murine models of chimeric antigen receptor (CAR) T cell therapy are widely applied, but are greatly limited by their inability to model the complex human tumor microenvironment and adequately predict safety and efficacy in patients. We therefore sought to develop a system that would enab...

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Bibliografske podrobnosti
izdano v:Mol Ther
Main Authors: Panjwani, M Kazim, Smith, Jenessa B, Schutsky, Keith, Gnanandarajah, Josephine, O'Connor, Colleen M, Powell, Daniel J, Mason, Nicola J
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5113111/
https://ncbi.nlm.nih.gov/pubmed/27401141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.146
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