Hyperglycemia Induces Skin Barrier Dysfunctions with Impairment of Epidermal Integrity in Non-Wounded Skin of Type 1 Diabetic Mice

Diabetes causes skin complications, including xerosis and foot ulcers. Ulcers complicated by infections exacerbate skin conditions, and in severe cases, limb/toe amputations are required to prevent the development of sepsis. Here, we hypothesize that hyperglycemia induces skin barrier dysfunction wi...

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Bibliographic Details
Published in:PLoS One
Main Authors: Okano, Junko, Kojima, Hideto, Katagi, Miwako, Nakagawa, Takahiko, Nakae, Yuki, Terashima, Tomoya, Kurakane, Takeshi, Kubota, Mamoru, Maegawa, Hiroshi, Udagawa, Jun
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5113047/
https://ncbi.nlm.nih.gov/pubmed/27846299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0166215
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