5'-Hydroxymethylcytosine Precedes Loss of CpG Methylation in Enhancers and Genes Undergoing Activation in Cardiomyocyte Maturation

BACKGROUND: Cardiomyocytes undergo major changes in DNA methylation during maturation and transition to a non-proliferative state after birth. 5’-hydroxylation of methylated cytosines (5hmC) is not only involved in DNA loss of CpG methylation but is also thought to be an epigenetic mark with unique...

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Pubblicato in:PLoS One
Autori principali: Kranzhöfer, David K., Gilsbach, Ralf, Grüning, Björn A., Backofen, Rolf, Nührenberg, Thomas G., Hein, Lutz
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5112848/
https://ncbi.nlm.nih.gov/pubmed/27851806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0166575
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