Safety and Immunogenicity of a rAd35-EnvA Prototype HIV-1 Vaccine in Combination with rAd5-EnvA in Healthy Adults (VRC 012)

BACKGROUND: VRC 012 was a Phase I study of a prototype recombinant adenoviral-vector serotype-35 (rAd35) HIV vaccine, the precursor to two recently published clinical trials, HVTN 077 and 083. On the basis of prior evaluation of multiclade rAd5 HIV vaccines, Envelope A (EnvA) was selected as the sta...

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Veröffentlicht in:PLoS One
Hauptverfasser: Crank, Michelle C., Wilson, Eleanor M. P., Novik, Laura, Enama, Mary E., Hendel, Cynthia S., Gu, Wenjuan, Nason, Martha C., Bailer, Robert T., Nabel, Gary J., McDermott, Adrian B., Mascola, John R., Koup, Richard A., Ledgerwood, Julie E., Graham, Barney S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5112788/
https://ncbi.nlm.nih.gov/pubmed/27846256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0166393
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