Acidic pH promotes intervertebral disc degeneration: Acid-sensing ion channel -3 as a potential therapeutic target

The aetiology of intervertebral disc (IVD) degeneration remains poorly understood. Painful IVD degeneration is associated with an acidic intradiscal pH but the response of NP cells to this aberrant microenvironmental factor remains to be fully characterised. The aim here was to address the hypothesi...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Gilbert, Hamish T. J., Hodson, Nathan, Baird, Pauline, Richardson, Stephen M., Hoyland, Judith A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5112591/
https://ncbi.nlm.nih.gov/pubmed/27853274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37360
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