The TNF-family ligand TL1A and its receptor DR3 promote T-cell mediated allergic immunopathology by enhancing differentiation and pathogenicity of IL-9 producing T cells()

The TNF family cytokine TL1A (Tnfsf15) costimulates T cells and type 2 innate lymphocytes (ILC2) through its receptor DR3 (Tnfrsf25). DR3-deficient mice have reduced T cell accumulation at the site of inflammation, and reduced ILC2-dependent immune responses in a number of models of autoimmune and a...

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Publicado no:J Immunol
Main Authors: Richard, Arianne C., Tan, Cuiyan, Hawley, Eric T., Gomez-Rodriguez, Julio, Goswami, Ritobrata, Yang, Xiang-ping, Cruz, Anthony C., Penumetcha, Pallavi, Hayes, Erika T., Pelletier, Martin, Gabay, Odile, Walsh, Matthew, Ferdinand, John R., Keane-Myers, Andrea, Choi, Yongwon, O'Shea, John J., Al-Shamkhani, Aymen, Kaplan, Mark H., Gery, Igal, Siegel, Richard M., Meylan, Françoise
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5112176/
https://ncbi.nlm.nih.gov/pubmed/25786692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401220
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