Targeting of Discoidin Domain Receptor 2 (DDR2) Prevents Myofibroblast Activation and Neovessel Formation During Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a lethal human disease with short survival time and few treatment options. Herein, we demonstrated that discoidin domain receptor 2 (DDR2), a receptor tyrosine kinase that predominantly transduces signals from fibrillar collagens, plays a critical role in the i...

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Vydáno v:Mol Ther
Hlavní autoři: Zhao, Hu, Bian, Huan, Bu, Xin, Zhang, Shuya, Zhang, Pan, Yu, Jiangtian, Lai, Xiaofeng, Li, Di, Zhu, Chuchao, Yao, Libo, Su, Jin
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5112036/
https://ncbi.nlm.nih.gov/pubmed/27350126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.109
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