Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism

We had reported elevated serum levels of the peptide neurotensin (NT) in children with autism spectrum disorders (ASD). Here, we show that NT stimulates primary human microglia, the resident immune cells of the brain, and the immortalized cell line of human microglia-SV40. NT (10 nM) increases the g...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Patel, Arti B., Tsilioni, Irene, Leeman, Susan E., Theoharides, Theoharis C.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111711/
https://ncbi.nlm.nih.gov/pubmed/27663735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604992113
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