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Roles for small noncoding RNAs in silencing of retrotransposons in the mammalian brain

Piwi-interacting RNAs (piRNAs), long thought to be restricted to germline, have recently been discovered in neurons of Aplysia, with a role in the epigenetic regulation of gene expression underlying long-term memory. We here ask whether piwi/piRNAs are also expressed and have functional roles in the...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Nandi, Sayan, Chandramohan, Dhruva, Fioriti, Luana, Melnick, Ari M., Hébert, Jean M., Mason, Christopher E., Rajasethupathy, Priyamvada, Kandel, Eric R.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111663/
https://ncbi.nlm.nih.gov/pubmed/27791114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1609287113
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