AAV-mediated Sirt1 overexpression in skeletal muscle activates oxidative capacity but does not prevent insulin resistance

Type 2 diabetes is characterized by triglyceride accumulation and reduced lipid oxidation capacity in skeletal muscle. SIRT1 is a key protein in the regulation of lipid oxidation and its expression is reduced in the skeletal muscle of insulin resistant mice. In this tissue, Sirt1 up-regulates the ex...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Ther Methods Clin Dev
Main Authors: Vilà, Laia, Roca, Carles, Elias, Ivet, Casellas, Alba, Lage, Ricardo, Franckhauser, Sylvie, Bosch, Fatima
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111573/
https://ncbi.nlm.nih.gov/pubmed/27909699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2016.72
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki