Copy number analysis by low coverage whole genome sequencing using ultra low-input DNA from formalin-fixed paraffin embedded tumor tissue

Unlocking clinically translatable genomic information, including copy number alterations (CNA), from formalin-fixed paraffin-embedded (FFPE) tissue is challenging due to low yields and degraded DNA. We describe a robust, cost-effective low-coverage whole genome sequencing (LC WGS) method for CNA det...

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Détails bibliographiques
Publié dans:Genome Med
Auteurs principaux: Kader, Tanjina, Goode, David L., Wong, Stephen Q., Connaughton, Jacquie, Rowley, Simone M., Devereux, Lisa, Byrne, David, Fox, Stephen B., Mir Arnau, Gisela, Tothill, Richard W., Campbell, Ian G., Gorringe, Kylie L.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2016
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Method
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111221/
https://ncbi.nlm.nih.gov/pubmed/27846907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-016-0375-z
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