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The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na(+) channels

Epithelial Na(+) channels mediate the transport of Na across epithelia in the kidney, gut, and lungs and are required for blood pressure regulation. They are inhibited by ubiquitin protein ligases, such as Nedd4 and Nedd4-2, with loss of this inhibition leading to hypertension. Here, we report that...

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Detalhes bibliográficos
Main Authors: Dinudom, Anuwat, Fotia, Andrew B., Lefkowitz, Robert J., Young, John A., Kumar, Sharad, Cook, David I.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC511069/
https://ncbi.nlm.nih.gov/pubmed/15284439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402178101
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