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Gamma reactivation using the spongy effect of KLF1-binding site sequence: an approach in gene therapy for beta-thalassemia

OBJECTIVE(S): β-thalassemia is one of the most common genetic disorders in the world. As one of the promising treatment strategies, fetal hemoglobin (Hb F) can be induced. The present study was an attempt to reactivate the γ-globin gene by introducing a gene construct containing KLF1 binding sites t...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Iran J Basic Med Sci
Main Authors: Heydari, Nasrin, Shariati, Laleh, Khanahmad, Hossein, Hejazi, Zahra, Shahbazi, Mansoureh, Salehi, Mansoor
פורמט: Artigo
שפה:Inglês
יצא לאור: Mashhad University of Medical Sciences 2016
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5110654/
https://ncbi.nlm.nih.gov/pubmed/27872702
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