Blocking Wnt Secretion Reduces Growth of Hepatocellular Carcinoma Cell Lines Mostly Independent of β-Catenin Signaling()

Aberrant activation of Wnt/β-catenin signaling plays a key role in the onset and development of hepatocellular carcinomas (HCC), with about half of them acquiring mutations in either CTNNB1 or AXIN1. However, it remains unclear whether these mutations impose sufficient β-catenin signaling or require...

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Vydáno v:Neoplasia
Hlavní autoři: Wang, Wenhui, Xu, Lei, Liu, Pengyu, Jairam, Kiran, Yin, Yuebang, Chen, Kan, Sprengers, Dave, Peppelenbosch, Maikel P., Pan, Qiuwei, Smits, Ron
Médium: Artigo
Jazyk:Inglês
Vydáno: Neoplasia Press 2016
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Original article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5110474/
https://ncbi.nlm.nih.gov/pubmed/27851986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2016.10.004
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