Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes

Dysregulated inflammatory responses are known to impair wound healing in diabetes, but the underlying mechanisms are poorly understood. Here we show that the antimicrobial protein REG3A controls TLR3-mediated inflammation after skin injury. This control is mediated by REG3A-induced SHP-1 protein, an...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Wu, Yelin, Quan, Yanchun, Liu, Yuanqi, Liu, Keiwei, Li, Hongquan, Jiang, Ziwei, Zhang, Tian, Lei, Hu, Radek, Katherine A., Li, Dongqing, Wang, Zhenhua, Lu, Jilong, Wang, Wang, Ji, Shizhao, Xia, Zhaofan, Lai, Yuping
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5109591/
https://ncbi.nlm.nih.gov/pubmed/27830702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13393
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