A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1(−/)(−) mice is correlated to increased cellular senescence

In contrast to other mouse models that are deficient in antioxidant enzymes, mice null for Cu/Zn-superoxide dismutase (Sod1(−/)(−) mice) show a major decrease in lifespan and several accelerated aging phenotypes. The goal of this study was to determine if cell senescence might be a contributing fact...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Zhang, Yiqiang, Unnikrishnan, Archana, Deepa, Sathyaseelan S., Liu, Yuhong, Li, Yan, Ikeno, Yuji, Sosnowska, Danuta, Van Remmen, Holly, Richardson, Arlan
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5109248/
https://ncbi.nlm.nih.gov/pubmed/27846439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2016.10.014
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