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N‐linked glycosylation of Kv1.2 voltage‐gated potassium channel facilitates cell surface expression and enhances the stability of internalized channels

KEY POINTS: Kv1.2 and related voltage‐gated potassium channels have a highly conserved N‐linked glycosylation site in the first extracellular loop, with complex glycosylation in COS‐7 cells similar to endogenous Kv1.2 glycosylation in hippocampal neurons. COS‐7 cells expressing Kv1.2 show a crucial...

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Bibliografiske detaljer
Udgivet i:J Physiol
Main Authors: Thayer, Desiree A., Yang, Shi‐Bing, Jan, Yuh Nung, Jan, Lily Y.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5108895/
https://ncbi.nlm.nih.gov/pubmed/27377235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP272394
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