Behavioral assessment of neuropathic pain, fatigue, and anxiety in experimental autoimmune encephalomyelitis (EAE) and attenuation by interleukin-10 gene therapy

Relapsing-remitting multiple sclerosis is commonly associated with motor impairments, neuropathic pain, fatigue, mood disorders, and decreased life expectancy. However, preclinical pharmacological studies predominantly rely on clinical scoring of motor deficit as the sole behavioral endpoint. Thus,...

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Publicado en:Brain Behav Immun
Autores principales: Grace, Peter M., Loram, Lisa C., Christianson, John P., Strand, Keith A., Flyer-Adams, Johanna G., Penzkover, Kathryn R., Forsayeth, John R., van Dam, Anne-Marie, Mahoney, Melissa J., Maier, Steven F., Chavez, Raymond A., Watkins, Linda R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5108696/
https://ncbi.nlm.nih.gov/pubmed/27189037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2016.05.012
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