Behavioral assessment of neuropathic pain, fatigue, and anxiety in experimental autoimmune encephalomyelitis (EAE) and attenuation by interleukin-10 gene therapy

Relapsing-remitting multiple sclerosis is commonly associated with motor impairments, neuropathic pain, fatigue, mood disorders, and decreased life expectancy. However, preclinical pharmacological studies predominantly rely on clinical scoring of motor deficit as the sole behavioral endpoint. Thus,...

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Vydáno v:Brain Behav Immun
Hlavní autoři: Grace, Peter M., Loram, Lisa C., Christianson, John P., Strand, Keith A., Flyer-Adams, Johanna G., Penzkover, Kathryn R., Forsayeth, John R., van Dam, Anne-Marie, Mahoney, Melissa J., Maier, Steven F., Chavez, Raymond A., Watkins, Linda R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5108696/
https://ncbi.nlm.nih.gov/pubmed/27189037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2016.05.012
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