Φορτώνει......
Programmed death-1 culls peripheral accumulation of high affinity autoreactive CD4 T cells to protect against autoimmunity
Self-reactive CD4 T cells are incompletely deleted during thymic development, and their peripheral seeding highlights the need for additional safeguards to avert autoimmunity. Here we show an essential role for the co-inhibitory molecule programmed death-1 (PD-1) in silencing the activation of high-...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Cell Rep |
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| Κύριοι συγγραφείς: | , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2016
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5108556/ https://ncbi.nlm.nih.gov/pubmed/27829150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.10.042 |
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