Impact of Increased Gastric pH on the Pharmacokinetics of Evacetrapib in Healthy Subjects

STUDY OBJECTIVE: To examine the effect of increased gastric pH on exposure to evacetrapib, a cholesteryl ester transfer protein inhibitor evaluated for the treatment of atherosclerotic heart disease. DESIGN: Open‐label, two‐treatment, two‐period, fixed‐sequence crossover study. SETTING: Clinical res...

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Detalhes bibliográficos
Publicado no:Pharmacotherapy
Main Authors: Small, David S., Royalty, Jane, Cannady, Ellen A., Hale, Christine, Wang, Ming‐Dauh, Downs, Delyn, Suico, Jeffrey G.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Original Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5108428/
https://ncbi.nlm.nih.gov/pubmed/27284735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/phar.1778
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