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TC-N19, a novel dual inhibitor of EGFR and cMET, efficiently overcomes EGFR-TKI resistance in non-small-cell lung cancer cells

Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) show a clinical benefit when used to treat patients with EGFR-mutated non-small-cell lung cancer (NSCLC), but this treatment unfortunately fails in patients with TKI-resistant tumors. We here provide evidence that TC-N19 (N19),...

詳細記述

保存先:
書誌詳細
出版年:Cell Death Dis
主要な著者: Wu, D-W, Chen, T-C, Huang, H-S, Lee, H
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5108342/
https://ncbi.nlm.nih.gov/pubmed/27362807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.192
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