Inhibition of JCPyV infection mediated by targeted viral genome editing using CRISPR/Cas9

Progressive multifocal leukoencephalopathy (PML) is a debilitating disease resulting from infection of oligodendrocytes by the JC polyomavirus (JCPyV). Currently, there is no anti-viral therapeutic available against JCPyV infection. The clustered regularly interspaced short palindromic repeat (CRISP...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Chou, Yi-ying, Krupp, Annabel, Kaynor, Campbell, Gaudin, Raphaël, Ma, Minghe, Cahir-McFarland, Ellen, Kirchhausen, Tom
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5107994/
https://ncbi.nlm.nih.gov/pubmed/27841295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36921
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