Glutathione-conjugating and membrane-remodeling activity of GDAP1 relies on amphipathic C-terminal domain

Mutations in the ganglioside-induced differentiation associated protein 1 (GDAP1) cause severe peripheral motor and sensory neuropathies called Charcot-Marie-Tooth disease. GDAP1 expression induces fission of mitochondria and peroxisomes by a currently elusive mechanism, while disease causing mutati...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Huber, Nina, Bieniossek, Christoph, Wagner, Konstanze Marion, Elsässer, Hans-Peter, Suter, Ueli, Berger, Imre, Niemann, Axel
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5107993/
https://ncbi.nlm.nih.gov/pubmed/27841286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36930
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