Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation

BACKGROUND: Mast cells are significantly involved in IgE-mediated allergic reactions; however, their roles in health and disease are incompletely understood. OBJECTIVE: We aimed to define the proteome contained in mast cell releasates upon activation to better understand the factors secreted by mast...

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Pubblicato in:J Allergy Clin Immunol
Autori principali: Shubin, Nicholas J., Glukhova, Veronika A., Clauson, Morgan, Truong, Phuong, Abrink, Magnus, Pejler, Gunnar, White, Nathan J., Deutsch, Gail H., Reeves, Stephen R., Vaisar, Tomas, James, Richard G., Piliponsky, Adrian M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5107356/
https://ncbi.nlm.nih.gov/pubmed/27302551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2016.03.051
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