CNS tau efflux via exosomes is likely increased in Parkinson disease but not in Alzheimer disease

BACKGROUND: Alzheimer disease (AD) and Parkinson disease (PD) involve tau pathology. Tau is detectable in blood, but its clearance from neuronal cells and the brain is poorly understood. METHODS: Tau efflux from the brain to the blood was evaluated by administering radioactively labeled and unlabele...

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Veröffentlicht in:Alzheimers Dement
Hauptverfasser: Shi, Min, Kovac, Andrej, Korff, Ane, Cook, Travis J., Ginghina, Carmen, Bullock, Kristin M., Yang, Li, Stewart, Tessandra, Zheng, Danfeng, Aro, Patrick, Atik, Anzari, Kerr, Kathleen F., Zabetian, Cyrus P., Peskind, Elaine R., Hu, Shu-Ching, Quinn, Joseph F., Galasko, Douglas R., Montine, Thomas J., Banks, William A., Zhang, Jing
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5107127/
https://ncbi.nlm.nih.gov/pubmed/27234211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2016.04.003
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