Marked Differences in C9orf72 Methylation Status and Isoform Expression between C9/ALS Human Embryonic and Induced Pluripotent Stem Cells

We established two human embryonic stem cell (hESC) lines with a GGGGCC expansion in the C9orf72 gene (C9), and compared them with haploidentical and unrelated C9 induced pluripotent stem cells (iPSCs). We found a marked difference in C9 methylation between the cells. hESCs and parental fibroblasts...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Cohen-Hadad, Yaara, Altarescu, Gheona, Eldar-Geva, Talia, Levi-Lahad, Ephrat, Zhang, Ming, Rogaeva, Ekaterina, Gotkine, Marc, Bartok, Osnat, Ashwal-Fluss, Reut, Kadener, Sebastian, Epsztejn-Litman, Silvina, Eiges, Rachel
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5106522/
https://ncbi.nlm.nih.gov/pubmed/27773700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.09.011
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