Establishment of Homozygote Mutant Human Embryonic Stem Cells by Parthenogenesis

We report on the derivation of a diploid 46(XX) human embryonic stem cell (HESC) line that is homozygous for the common deletion associated with Spinal muscular atrophy type 1 (SMA) from a pathenogenetic embryo. By characterizing the methylation status of three different imprinted loci (MEST, SNRPN...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Epsztejn-Litman, Silvina, Cohen-Hadad, Yaara, Aharoni, Shira, Altarescu, Gheona, Renbaum, Paul, Levy-Lahad, Ephrat, Schonberger, Oshrat, Eldar-Geva, Talia, Zeligson, Sharon, Eiges, Rachel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4608834/
https://ncbi.nlm.nih.gov/pubmed/26473610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138893
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