CNOT3-Dependent mRNA Deadenylation Safeguards the Pluripotent State

Poly(A) tail length and mRNA deadenylation play important roles in gene regulation. However, how they regulate embryonic development and pluripotent cell fate is not fully understood. Here we present evidence that CNOT3-dependent mRNA deadenylation governs the pluripotent state. We show that CNOT3,...

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Publicado en:Stem Cell Reports
Autores principales: Zheng, Xiaofeng, Yang, Pengyi, Lackford, Brad, Bennett, Brian D., Wang, Li, Li, Hui, Wang, Yu, Miao, Yiliang, Foley, Julie F., Fargo, David C., Jin, Ying, Williams, Carmen J., Jothi, Raja, Hu, Guang
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5106518/
https://ncbi.nlm.nih.gov/pubmed/27746116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.09.007
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