CNOT3-Dependent mRNA Deadenylation Safeguards the Pluripotent State

Poly(A) tail length and mRNA deadenylation play important roles in gene regulation. However, how they regulate embryonic development and pluripotent cell fate is not fully understood. Here we present evidence that CNOT3-dependent mRNA deadenylation governs the pluripotent state. We show that CNOT3,...

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Gepubliceerd in:Stem Cell Reports
Hoofdauteurs: Zheng, Xiaofeng, Yang, Pengyi, Lackford, Brad, Bennett, Brian D., Wang, Li, Li, Hui, Wang, Yu, Miao, Yiliang, Foley, Julie F., Fargo, David C., Jin, Ying, Williams, Carmen J., Jothi, Raja, Hu, Guang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5106518/
https://ncbi.nlm.nih.gov/pubmed/27746116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.09.007
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