CNOT3-Dependent mRNA Deadenylation Safeguards the Pluripotent State

Poly(A) tail length and mRNA deadenylation play important roles in gene regulation. However, how they regulate embryonic development and pluripotent cell fate is not fully understood. Here we present evidence that CNOT3-dependent mRNA deadenylation governs the pluripotent state. We show that CNOT3,...

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Bibliografski detalji

Glavni autori:	Xiaofeng Zheng, Pengyi Yang, Brad Lackford, Brian D. Bennett, Li Wang, Hui Li, Yu Wang, Yiliang Miao, Julie F. Foley, David C. Fargo, Ying Jin, Carmen J. Williams, Raja Jothi, Guang Hu
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2016-11-01
Serija:	Stem Cell Reports
Teme:	pluripotent state pre-implantation development embryonic stem cell mRNA deadenylation
Online pristup:	http://www.sciencedirect.com/science/article/pii/S2213671116302132
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