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CNOT3-Dependent mRNA Deadenylation Safeguards the Pluripotent State

Poly(A) tail length and mRNA deadenylation play important roles in gene regulation. However, how they regulate embryonic development and pluripotent cell fate is not fully understood. Here we present evidence that CNOT3-dependent mRNA deadenylation governs the pluripotent state. We show that CNOT3,...

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Principais autores: Xiaofeng Zheng, Pengyi Yang, Brad Lackford, Brian D. Bennett, Li Wang, Hui Li, Yu Wang, Yiliang Miao, Julie F. Foley, David C. Fargo, Ying Jin, Carmen J. Williams, Raja Jothi, Guang Hu
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016-11-01
coleção:Stem Cell Reports
Assuntos:
pluripotent state
pre-implantation development
embryonic stem cell
mRNA deadenylation
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2213671116302132
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