Soluble phospho-tau from Alzheimer’s disease hippocampus drives microglial degeneration

The role of microglial cells in the development and progression of Alzheimer’s disease (AD) has not been elucidated. Here, we demonstrated the existence of a weak microglial response in human AD hippocampus which is in contrast to the massive microglial activation observed in APP-based models. Most...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Sanchez-Mejias, Elisabeth, Navarro, Victoria, Jimenez, Sebastian, Sanchez-Mico, Maria, Sanchez-Varo, Raquel, Nuñez-Diaz, Cristina, Trujillo-Estrada, Laura, Davila, Jose Carlos, Vizuete, Marisa, Gutierrez, Antonia, Vitorica, Javier
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2016
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5106501/
https://ncbi.nlm.nih.gov/pubmed/27743026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-016-1630-5
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