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FUMARASE DEFICIENT UTERINE LEIOMYOMAS – AN IMMUNOHISTO-CHEMICAL, MOLECULAR GENETIC, AND CLINICOPATHOLOGIC STUDY OF 86 CASES

Loss-of-function germline mutations in the fumarase (FH)-gene of the Krebs cycle characterize hereditary leiomyomatosis and renal cell cancer (HLRCC)-syndrome. Fumarase (FH)-deficiency can be diagnosed by the loss of immunohistochemical expression. In this study, we investigated the occurrence and c...

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Publicat a:Am J Surg Pathol
Autors principals: Miettinen, Markku, Felisiak-Golabek, Anna, Wasag, Bartosz, Chmara, Magdalena, Wang, Zengfeng, Butzow, Ralf, Lasota, Jerzy
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5106328/
https://ncbi.nlm.nih.gov/pubmed/27454940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PAS.0000000000000703
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