Combined Changes in Chloride Regulation and Neuronal Excitability Enable Primary Afferent Depolarization to Elicit Spiking without Compromising its Inhibitory Effects

The central terminals of primary afferent fibers experience depolarization upon activation of GABA(A) receptors (GABA(A)R) because their intracellular chloride concentration is maintained above electrochemical equilibrium. Primary afferent depolarization (PAD) normally mediates inhibition via sodium...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:PLoS Comput Biol
Autori principali: Takkala, Petri, Zhu, Yi, Prescott, Steven A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5105942/
https://ncbi.nlm.nih.gov/pubmed/27835641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005215
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi