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Combined Changes in Chloride Regulation and Neuronal Excitability Enable Primary Afferent Depolarization to Elicit Spiking without Compromising its Inhibitory Effects
The central terminals of primary afferent fibers experience depolarization upon activation of GABA(A) receptors (GABA(A)R) because their intracellular chloride concentration is maintained above electrochemical equilibrium. Primary afferent depolarization (PAD) normally mediates inhibition via sodium...
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| Publié dans: | PLoS Comput Biol |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5105942/ https://ncbi.nlm.nih.gov/pubmed/27835641 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005215 |
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