Incorporating Functional Annotations for Fine-Mapping Causal Variants in a Bayesian Framework Using Summary Statistics

Functional annotations have been shown to improve both the discovery power and fine-mapping accuracy in genome-wide association studies. However, the optimal strategy to incorporate the large number of existing annotations is still not clear. In this study, we propose a Bayesian framework to incorpo...

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Bibliographic Details
Published in:Genetics
Main Authors: Chen, Wenan, McDonnell, Shannon K., Thibodeau, Stephen N., Tillmans, Lori S., Schaid, Daniel J.
Format: Artigo
Language:Inglês
Published: Genetics Society of America 2016
Subjects:
Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5105870/
https://ncbi.nlm.nih.gov/pubmed/27655946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.116.188953
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