Chitinase-3-like 1 protein (CHI3L1) locus influences cerebrospinal fluid levels of YKL-40

BACKGROUND: Alzheimer’s disease (AD) pathology appears several years before clinical symptoms, so identifying ways to detect individuals in the preclinical stage is imperative. The cerebrospinal fluid (CSF) Tau/Aβ(42) ratio is currently the best known predictor of AD status and cognitive decline, an...

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Pubblicato in:BMC Neurol
Autori principali: Deming, Yuetiva, Black, Kathleen, Carrell, David, Cai, Yefei, Del-Aguila, Jorge L., Fernandez, Maria Victoria, Budde, John, Ma, ShengMei, Saef, Benjamin, Howells, Bill, Bertelsen, Sarah, Huang, Kuan-lin, Sutphen, Courtney L., Tarawneh, Rawan, Fagan, Anne M., Holtzman, David M., Morris, John C., Goate, Alison M., Dougherty, Joseph D., Cruchaga, Carlos
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5105244/
https://ncbi.nlm.nih.gov/pubmed/27832767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12883-016-0742-9
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