Impact of mutational profiles on response of primary oestrogen receptor-positive breast cancers to oestrogen deprivation

Pre-surgical studies allow study of the relationship between mutations and response of oestrogen receptor-positive (ER+) breast cancer to aromatase inhibitors (AIs) but have been limited to small biopsies. Here in phase I of this study, we perform exome sequencing on baseline, surgical core-cuts and...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Gellert, Pascal, Segal, Corrinne V., Gao, Qiong, López-Knowles, Elena, Martin, Lesley-Ann, Dodson, Andrew, Li, Tiandao, Miller, Christopher A., Lu, Charles, Mardis, Elaine R., Gillman, Alexa, Morden, James, Graf, Manuela, Sidhu, Kally, Evans, Abigail, Shere, Michael, Holcombe, Christopher, McIntosh, Stuart A., Bundred, Nigel, Skene, Anthony, Maxwell, William, Robertson, John, Bliss, Judith M., Smith, Ian, Dowsett, Mitch
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5105193/
https://ncbi.nlm.nih.gov/pubmed/27827358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13294
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