Kinetics of recruitment and allosteric activation of ARHGEF25 isoforms by the heterotrimeric G-protein Gαq

Rho GTPases are master regulators of the eukaryotic cytoskeleton. The activation of Rho GTPases is governed by Rho guanine nucleotide exchange factors (GEFs). Three RhoGEF isoforms are produced by the gene ARHGEF25; p63RhoGEF(580), GEFT and a recently discovered longer isoform of 619 amino acids (p6...

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Udgivet i:Sci Rep
Main Authors: van Unen, Jakobus, Yin, Taofei, Wu, Yi I., Mastop, Marieke, Gadella, Theodorus W. J., Goedhart, Joachim
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5105084/
https://ncbi.nlm.nih.gov/pubmed/27833100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36825
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