Variable Dependence of Signaling Output on Agonist Occupancy of Ste2p, a G Protein-coupled Receptor in Yeast

We report here on the relationship between ligand binding and signaling responses in the yeast pheromone response pathway, a well characterized G protein-coupled receptor system. Responses to agonist (α-factor) by cells expressing widely varying numbers of receptors depend primarily on fractional oc...

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Udgivet i:J Biol Chem
Main Authors: Sridharan, Rajashri, Connelly, Sara M., Naider, Fred, Dumont, Mark E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5104947/
https://ncbi.nlm.nih.gov/pubmed/27646004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.733006
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