Identification of Small Molecule Inhibitors of Human Cytochrome c Oxidase That Target Chemoresistant Glioma Cells

The enzyme cytochrome c oxidase (CcO) or complex IV (EC 1.9.3.1) is a large transmembrane protein complex that serves as the last enzyme in the respiratory electron transport chain of eukaryotic mitochondria. CcO promotes the switch from glycolytic to oxidative phosphorylation (OXPHOS) metabolism an...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Oliva, Claudia R., Markert, Tahireh, Ross, Larry J., White, E. Lucile, Rasmussen, Lynn, Zhang, Wei, Everts, Maaike, Moellering, Douglas R., Bailey, Shannon M., Suto, Mark J., Griguer, Corinne E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5104942/
https://ncbi.nlm.nih.gov/pubmed/27679486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.749978
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