Model Linking Plasma and Intracellular Tenofovir/Emtricitabine with Deoxynucleoside Triphosphates

The coformulation of the nucleos(t)ide analogs (NA) tenofovir (TFV) disoproxil fumarate (TDF) and emtricitabine (FTC) is approved for HIV-infection treatment and prevention. Plasma TFV and FTC undergo complicated hybrid processes to form, accumulate, and retain as their active intracellular anabolit...

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Udgivet i:PLoS One
Main Authors: Chen, Xinhui, Seifert, Sharon M., Castillo-Mancilla, Jose R., Bushman, Lane R., Zheng, Jia-Hua, Kiser, Jennifer J., MaWhinney, Samantha, Anderson, Peter L.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5104339/
https://ncbi.nlm.nih.gov/pubmed/27832147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0165505
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