Intracellular Tenofovir and Emtricitabine Anabolites in Genital, Rectal, and Blood Compartments from First Dose to Steady State

The pharmacokinetics (PK) of tenofovir-diphosphate (TFV-DP) and emtricitabine-triphosphate (FTC-TP), the active anabolites of tenofovir disoproxil fumarate (TDF), and emtricitabine (FTC) in blood, genital, and rectal compartments was determined in HIV-positive and seronegative adults who undertook a...

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Publicado en:AIDS Res Hum Retroviruses
Autores principales: Seifert, Sharon M., Chen, Xinhui, Meditz, Amie L., Castillo-Mancilla, Jose R., Gardner, Edward M., Predhomme, Julie A., Clayton, Carolyn, Austin, Gregory, Palmer, Brent E., Zheng, Jia-Hua, Klein, Brandon, Kerr, Becky J., Guida, L. Anthony, Rower, Caitlin, Rower, Joseph E., Kiser, Jennifer J., Bushman, Lane R., MaWhinney, Samantha, Anderson, Peter L.
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc. 2016
Materias:
PReP
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5067852/
https://ncbi.nlm.nih.gov/pubmed/27526873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2016.0008
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