Small cell lung cancer transformation and the T790M mutation: A case report of two acquired mechanisms of TKI resistance detected in a tumor rebiopsy and plasma sample of EGFR-mutant lung adenocarcinoma

The present study describes the case of a 45-year-old man diagnosed with metastatic lung adenocarcinoma, which harbored a deletion within exon 19 of the epidermal growth factor receptor (EGFR) gene. The patient was subsequently treated with gefitinib (250 mg/day orally from May 2013 to March 2014),...

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Detalhes bibliográficos
Publicado no:Oncol Lett
Main Authors: Alì, Greta, Bruno, Rossella, Giordano, Mirella, Prediletto, Irene, Marconi, Letizia, Zupo, Simonetta, Fedeli, Franco, Ribechini, Alessandro, Chella, Antonio, Fontanini, Gabriella
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5104225/
https://ncbi.nlm.nih.gov/pubmed/27895763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2016.5193
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