Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires

The design of immunogens that elicit broadly reactive neutralizing antibodies (bnAbs) has been a major obstacle to HIV-1 vaccine development. One approach to assess potential immunogens is to use mice expressing precursors of human bnAbs as vaccination models. The bnAbs of the VRC01-class derive fro...

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Publicado en:Cell
Main Authors: Tian, Ming, Cheng, Cheng, Chen, Xuejun, Duan, Hongying, Cheng, Hwei-Ling, Dao, Mai, Sheng, Zizhang, Kimble, Michael, Wang, Lingshu, Lin, Sherry, Schmidt, Stephen D., Du, Zhou, Joyce, M. Gordon, Chen, Yiwei, DeKosky, Brandon J., Chen, Yimin, Normandin, Erica, Cantor, Elizabeth, Chen, Rita E., Doria-Rose, Nicole A., Zhang, Yi, Shi, Wei, Kong, Wing-Pui, Choe, Misook, Henry, Amy R., Laboune, Farida, Georgiev, Ivelin S., Huang, Pei-Yi, Jain, Suvi, McGuire, Andrew T., Georgeson, Eric, Menis, Sergey, Douek, Daniel C., Schief, William R., Stamatatos, Leonidas, Kwong, Peter D., Shapiro, Lawrence, Haynes, Barton F., Mascola, John R., Alt, Frederick W.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5103708/
https://ncbi.nlm.nih.gov/pubmed/27610571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.07.029
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